Set after the events of the first game, Kang the Conqueror is traveling through different timelines and realities, conquering and kidnapping its most famous cities and then uniting them in one place: Chronopolis. Thanks to this, various superheroes are taken from their respective "homes" and brought there, where they must work together to prevent the Conqueror's threat, who plans on taking over not just Chronopolis, but the universe. Along the way, the heroes manage to get a hold of some of Kang's technology, making it possible to age and de-age Groot and summon counterparts.
- PlayStation 4
- Xbox One
- Nintendo Switch
- The game features a new cast in the form of Non-Union actors, as the voice cast from the previous game didn't return, because it was affected by the 2016–17 video game voice actor strike from the Screen Actors Guild‐American Federation of Television and Radio Artists (SAG-AFTRA).